Not all stem cells are the same. Discover why Dezawa MuseCells — a naturally occurring, pluripotent-like cell population — represent a distinct advancement over conventional mesenchymal stem cells.
Muse cells (Multilineage-differentiating Stress-Enduring cells) are a rare, naturally occurring population of repair cells found in adult human tissue, first characterized by Professor Mari Dezawa at Tohoku University in 2010. They are identified by the surface marker SSEA-3 and possess the unique ability to differentiate into cells of all three germ layers — endoderm, mesoderm, and ectoderm — without genetic reprogramming.
Unlike conventional stem cells, Muse cells actively home to damaged tissue via S1P/S1PR2 signaling, making them capable of targeted repair throughout the body. Because they are already present in your bone marrow, peripheral blood, and connective tissues, they represent the body’s natural repair system amplified through precise laboratory isolation.
While both Muse cells and mesenchymal stem cells (MSCs) play important roles in regenerative medicine, they are biologically distinct in several critical ways:
| Property | Muse Cells | Conventional MSCs |
|---|---|---|
| Surface Marker | SSEA-3+ | CD105+, CD73+, CD90+ |
| Differentiation | Triploblastic (all 3 germ layers) | Mesenchymal lineages only |
| Homing Mechanism | Active S1P/S1PR2 signaling | Passive entrapment in lung capillaries |
| Engraftment Rate (IV) | ~14.5% at injured site | <1% |
| Tumorigenicity | None — no teratoma formation in standard assays | None |
| Immune Privilege | High HLA-G expression (allogeneic compatible) | Moderate |
| IV Delivery | Clinically viable due to active homing | Limited — cells aggregate in lungs |
Miami Stem Cell is an authorized clinical provider of authentic Dezawa MuseCells sourced through MuseCell Innovations — the exclusive licensee of Professor Dezawa’s patented SSEA-3 isolation technology. Every vial includes a lot-specific Certificate of Analysis verifying SSEA-3 percentage, cell count, viability, and sterility.
Over 120 peer-reviewed publications and multiple Phase II human clinical trials — including studies in stroke, myocardial infarction, ALS, and spinal cord injury — have demonstrated the safety profile of Dezawa MuseCells. A critical finding across all studies: Muse cells are non-tumorigenic, even in standard teratoma assays where embryonic stem cells and iPSCs routinely form tumors.
This safety profile is not accidental. As described in the scientific white paper by Dr. Joseph Purita, MD, the distinct isolation protocol developed at Tohoku University selectively enriches stress-enduring cells while eliminating unstable populations — a biological safeguard built into the manufacturing process.
Multilineage-differentiating Stress-Enduring. “Multilineage-differentiating” refers to their ability to become many different cell types. “Stress-Enduring” refers to their survival under conditions that kill most cells.
The literature describes them as pluripotent-like rather than fully pluripotent. They can differentiate into cells of all three germ layers but do not form teratomas — a distinction from embryonic and induced pluripotent stem cells.
Clinical research has explored Muse cells for ischemic stroke, acute myocardial infarction, amyotrophic lateral sclerosis (ALS), spinal cord injury, and various orthopedic and neurodegenerative conditions.
Authentic Dezawa MuseCells are defined by the patented SSEA-3 isolation protocol developed by Professor Mari Dezawa. Each lot is verified through flow cytometry for SSEA-3 expression, cell count, viability, and sterility testing.
Dezawa MuseCells are available through authorized clinical providers under Florida SB 1768, which permits licensed physicians to administer certain stem cell therapies for orthopedic conditions, wound care, and pain management while adhering to specified regulatory standards.
Our treatments are out-of-pocket and not covered by insurance. During your free consultation, we will provide a detailed treatment plan and pricing based on your specific needs.
Take the first step toward understanding how Dezawa MuseCells may support your recovery. Schedule a free consultation with our team today.
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Our treatments are out-of-pocket and not covered by insurance.