The Meniscus Tear: A Review of Stem Cell Therapies

 

 

 

Meniscal injuries have posed a challenging problem for many years, especially considering that historically the meniscus was considered to be a structure with no important role in the knee joint. This led to earlier treatments aiming at the removal of the entire structure in a procedure known as a meniscectomy. However, with the current understanding of the function and roles of the meniscus, meniscectomy has been identified to accelerate joint degradation significantly and is no longer a preferred treatment option in meniscal tears. Current therapies are now focused to regenerate, repair, or replace the injured meniscus to restore its native function. Repairs have improved in technique and materials over time, with various implant devices being utilized and developed. More recently, strategies have applied stem cells, tissue engineering, and their combination to potentiate healing to achieve superior quality repair tissue and retard the joint degeneration associated with an injured or inadequately functioning meniscus. Accordingly, the purpose of this current review is to summarize the current available pre-clinical and clinical literature using stem cells and tissue engineering for meniscal repair and regeneration.

To read the entire article, please click the link below:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016630/

 

Mesenchymal stem cells in osteoarthritis therapy: a review

Osteoarthritis (OA) is a chronic joint disease that generally occurs worldwide with pain and disability. The progression is slow, and it is mostly diagnosed midlife and often disturbs the knees, hips, feet, hands, and spine. Sex, age, obesity, occupation, and hereditary factors are risk factors that increase the opportunity for OA. Physical examinations involving X-rays and MRI, joint fluid analysis and blood tests are common tools for the diagnosis of OA. Interventions including exercise, manual therapy, lifestyle modification, and medication can help relieve pain and maintain mobility in the affected joints, yet none of the therapies enables the promotion of regeneration of degenerated tissues. Mesenchymal stem cells (MSCs) are a promising source for the treatment of OA due to their multipotency for differentiation into chondrocytes and their ability to modulate the immune system. Herein, we review the pathogenesis and treatment of OA and address the current status of MSCs as a novel potential therapeutic agent in OA treatment.

To read the entire published study, please click on the link below:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868850/

 

 

Can stem cell therapies help my chronic back and neck pain?

Discs in the neck and lower back may degenerate, causing chronic back and neck pain. In the United States, 500,000 spinal fusion surgeries and 400,000 lumbar discectomies are performed every year for people who are dealing with chronic back pain due to disc degeneration. Regenerative medicine offers an alternative to surgery, and the innovation provided by stem cell therapies is an exciting new way to help people who are suffering from chronic back and neck pain that are caused by degenerative disc diseases in the neck and back.

Regenerative medicine is a relatively new branch of translational medicine that is focused on helping the body’s own ability to repair itself by regenerating healthy tissue for the restoration of function. Regenerative therapy may involve injecting stem cells into damaged areas in order to help regenerate healthy tissue.

Undifferentiated cells, stem cells hold the potential to be turned into specialized cells that can form a variety of different tissues. Stem cells may be adult stem cells or embryonic stem cells. Since embryonic stem cells come from human fetuses, there are numerous ethical concerns with using them. Instead, adult stem cells are used for regenerative therapies.

Regenerative stem cell therapy involves taking a patient’s stem cells by removing cells from the patient’s bone marrow. After the cells are extracted, it is then centrifuged in order to separate and identify the specific cells that can help to heal the damaged tissue. The cells are then injected into the degenerated disc, which stimulates the regeneration of the disc’s collagen. As the collagen is regenerated in the damaged disc, its function should slowly be restored.

At Miami Stem Cell our signature stem cell procedure is called “Super Marrow” and it is ideal to treat back / spine related problems. For more information, please visit: www.stemcellmia.com

What is osteoarthritis (OA)?

 

 

Osteoarthritis (OA) is the most common form of arthritis. Some people call it degenerative joint disease or “wear and tear” arthritis. It occurs most frequently in the hands, hips, and knees.

With OA, the cartilage within a joint begins to break down and the underlying bone begins to change. These changes usually develop slowly and get worse over time. OA can cause pain, stiffness, and swelling. In some cases it also causes reduced function and disability; some people are no longer able to do daily tasks or work.

What are the signs and symptoms of OA?

  • Pain or aching
  • Stiffness
  • Decreased range of motion (or flexibility)
  • Swelling

How many people have OA?

OA affects over 32.5 million US adults.

What causes OA?

OA is caused by damage or breakdown of joint cartilage between bones.

To read the entire article, please click on the following:

https://www.cdc.gov/arthritis/basics/osteoarthritis.htm?fbclid=IwAR0eh-2t1_i5XqPncPy29mBZ1rfNeFQiBIvLzNyeJYFJIEMaQU48TNZNlDs#number

 

How does Stem Cell & PRP therapies work?

Minimally invasive, cell-based therapy introduces cells from one part of the body to the impacted area, for accelerated restoration. Stem cells work by releasing proteins called growth factors to help heal, repair and restore damaged areas. An innovative, surgery-free treatment that helps your body restore itself by isolating stem cells from one location of the body to the area of disease, injury or inflammation. This process uses a minimally invasive surgical technique, conducted right in our clinic.

When you think Regenerative Medicine, names like Kobe Bryant , Chris Johnson, Alex Rodriguez, and Chauncey Billups should all come to mind. These four athletes (among many others) have used cell therapy to make unlikely recoveries from severe sports-related injuries. But how? To begin, cells are the basic structural and functional units of all living organisms. Cell therapy entails the injection of cellular material into a patient’s body. In Regenerative Medicine, the objective is to improve the biological function of damaged or degraded tissues and organs.

To this end, the injection of cellular material, either from the patient (autologous) or from a donor (allogeneic), may be employed to address a range of conditions. Cell therapies primarily fall into two categories: Platelet-Rich Plasma and Stem Cell. PLATELET-RICH PLASMA (PRP)

Platelet-Rich Plasma (PRP) or Platelet Lysate Injection Treatments is a growth factor based treatment, where blood is drawn from a patient and then placed in a centrifuge where it is spun out to separate the platelets from the remainder of the blood. To complete the process the doctor takes the platelets and recombines them with a lower volume of blood plasma to create a fluid with a higher-than-normal concentration of platelets, thus growth factors (special proteins that trigger growth and healing in the body) and then injected into damaged tissue for to help expedite the process of rebuilding collagen and tissue.

To see if you are a candidate for this type of revolutionary therapy, please contact Miami Stem Cell (305) 598-7777 to schedule a free evaluation.

 

What is a herniated disc?

 

Herniated disc is a disease in which part of the intervertebral disc (nucleus pulposus), which is located between the vertebrae, moves towards the nerve root, presses it and produces neurological lesions derived from this injury. They can be contained (only deformation, also called disc protrusion) or with rupture.

Hernias correspond to the greatest disability in people under 45 years of age. About 1.10% of the population has chronic disability for this reason. They are common in people with genetic diseases that affect connective tissue such as Ehlers-Danlos syndrome and joint hypermobility syndrome.

The hernia causes pain in the lower back. The periosteum of the vertebrae, the joints, the dura mater, the fibrous annulus, the posterior longitudinal vertebral ligament, and the lumbar muscles of the spine are painful due to inflammation. A herniated disc can produce a series of clinical manifestations, among the most frequent are lumbago and sciatica.

If you or someone you know suffers from this painful condition, please call (305) 598-7777 for a consultation with the experts at Miami Stem Cell to evaluate whether a Regenerative Medicine treatment could help you.