Mesenchymal stem cells in osteoarthritis therapy: a review

Osteoarthritis (OA) is a chronic joint disease that generally occurs worldwide with pain and disability. The progression is slow, and it is mostly diagnosed midlife and often disturbs the knees, hips, feet, hands, and spine. Sex, age, obesity, occupation, and hereditary factors are risk factors that increase the opportunity for OA. Physical examinations involving X-rays and MRI, joint fluid analysis and blood tests are common tools for the diagnosis of OA. Interventions including exercise, manual therapy, lifestyle modification, and medication can help relieve pain and maintain mobility in the affected joints, yet none of the therapies enables the promotion of regeneration of degenerated tissues. Mesenchymal stem cells (MSCs) are a promising source for the treatment of OA due to their multipotency for differentiation into chondrocytes and their ability to modulate the immune system. Herein, we review the pathogenesis and treatment of OA and address the current status of MSCs as a novel potential therapeutic agent in OA treatment.

To read the entire published study, please click on the link below:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868850/

 

 

What is osteoarthritis (OA)?

 

 

Osteoarthritis (OA) is the most common form of arthritis. Some people call it degenerative joint disease or “wear and tear” arthritis. It occurs most frequently in the hands, hips, and knees.

With OA, the cartilage within a joint begins to break down and the underlying bone begins to change. These changes usually develop slowly and get worse over time. OA can cause pain, stiffness, and swelling. In some cases it also causes reduced function and disability; some people are no longer able to do daily tasks or work.

What are the signs and symptoms of OA?

  • Pain or aching
  • Stiffness
  • Decreased range of motion (or flexibility)
  • Swelling

How many people have OA?

OA affects over 32.5 million US adults.

What causes OA?

OA is caused by damage or breakdown of joint cartilage between bones.

To read the entire article, please click on the following:

https://www.cdc.gov/arthritis/basics/osteoarthritis.htm?fbclid=IwAR0eh-2t1_i5XqPncPy29mBZ1rfNeFQiBIvLzNyeJYFJIEMaQU48TNZNlDs#number

 

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