Bone Marrow Aspirate Concentrate for the Treatment of Knee Osteoarthritis: A Systematic Review

 

A systematic review was performed by searching the PubMed, Embase, and Cochrane Library databases up to July 2020 to identify human studies that assessed the clinical outcomes of isolated BMAC injection for the treatment of knee OA. The electronic search strategy used was “bone marrow aspirate concentrate knee osteoarthritis.”

Eight studies met the inclusion criteria, including a total of 299 knees with a mean follow-up of 12.9 months (range, 6-30 months). Of all patient-reported outcomes assessed across studies, 34 of 36 (94.4%) demonstrated significant improvement from baseline to latest follow-up (P < .05). Five studies evaluating numerical pain scores (visual analog scale and Numeric Rating Scale) reported significant improvements in pain level at final follow-up (P < .01). However, 3 comparative studies evaluating BMAC in relation to other therapeutic injections failed to demonstrate the clinical superiority of BMAC.

The BMAC injection is effective in improving pain and patient-reported outcomes in patients with knee OA at short- to midterm follow-up. Nevertheless, BMAC has not demonstrated clinical superiority in relation to other biologic therapies commonly used in the treatment of OA, including platelet-rich plasma and microfragmented adipose tissue, or in relation to placebo. The high cost of the BMAC injection in comparison with other biologic and nonoperative treatment modalities may limit its utility despite demonstrable clinical benefit.

 

Stem Cell Transplant Trial Enrolls First MS Patient in Minnesota.

A clinical trial investigating patient-derived stem cell transplants for the treatment of people with severe relapsing forms of multiple sclerosis (MS) has enrolled a patient in Minnesota.

The patient was enrolled at the University of Minnesota Medical School, one of two trial sites in the state. An additional 18 sites in the U.S. and one in the U.K. also are, or soon will be, recruiting participants for the BEAT-MS Phase 3 trial (NCT04047628). More information is available here.

The prevalence of MS is greater in Midwestern states than in the general U.S. population. It is estimated that “about 309 people [of] every 100,000 in the United States have MS, but in the Midwest, … we rank second in prevalence — the numbers increase to 353 people out of every 100,000 that are affected by this disease,” Flavia Nelson, MD, a professor of neurology and the study’s lead investigator, said in a press release.

More than a dozen disease-modifying therapies have been approved for the treatment of MS. However, in addition to their elevated costs, some of these therapies are not very effective at treating severe forms of relapsing MS. A stem cell transplant has been explored as a treatment alternative for MS patients who failed to respond to conventional disease-modifying therapies (DMT). By reseting the immune system so that the central nervous system is no longer attacked, this would provide a more effective and longer-lasting alternative to patients.

However, whether a stem cell transplant — also known as an autologous (patient-derived) hematopoietic stem cell transplant — is more effective than conventional disease-modifying therapies remains unclear. Their safety and costs also have not been compared.

To read the entire article, please click on the link below:

https://multiplesclerosisnewstoday.com/news-posts/2021/06/11/first-patient-enrolled-minnesota-ms-stem-cell-transplant/

 

How does Stem Cell & PRP therapies work?

Minimally invasive, cell-based therapy introduces cells from one part of the body to the impacted area, for accelerated restoration. Stem cells work by releasing proteins called growth factors to help heal, repair and restore damaged areas. An innovative, surgery-free treatment that helps your body restore itself by isolating stem cells from one location of the body to the area of disease, injury or inflammation. This process uses a minimally invasive surgical technique, conducted right in our clinic.

When you think Regenerative Medicine, names like Kobe Bryant , Chris Johnson, Alex Rodriguez, and Chauncey Billups should all come to mind. These four athletes (among many others) have used cell therapy to make unlikely recoveries from severe sports-related injuries. But how? To begin, cells are the basic structural and functional units of all living organisms. Cell therapy entails the injection of cellular material into a patient’s body. In Regenerative Medicine, the objective is to improve the biological function of damaged or degraded tissues and organs.

To this end, the injection of cellular material, either from the patient (autologous) or from a donor (allogeneic), may be employed to address a range of conditions. Cell therapies primarily fall into two categories: Platelet-Rich Plasma and Stem Cell. PLATELET-RICH PLASMA (PRP)

Platelet-Rich Plasma (PRP) or Platelet Lysate Injection Treatments is a growth factor based treatment, where blood is drawn from a patient and then placed in a centrifuge where it is spun out to separate the platelets from the remainder of the blood. To complete the process the doctor takes the platelets and recombines them with a lower volume of blood plasma to create a fluid with a higher-than-normal concentration of platelets, thus growth factors (special proteins that trigger growth and healing in the body) and then injected into damaged tissue for to help expedite the process of rebuilding collagen and tissue.

To see if you are a candidate for this type of revolutionary therapy, please contact Miami Stem Cell (305) 598-7777 to schedule a free evaluation.

 

Let Your Own Body Heal You at Miami Stem Cell®

Regenerative Medicine is the field of expertise at Miami Stem Cell® and our team of highly qualified medical professionals is devoted to the well-being of each one of our patients. Our mission is to provide all of our patients with top-quality healthcare in order to improve their overall quality of life.

We pride ourselves in offering innovative medical procedures and we make it our goal to try and solve the problem and alleviate the condition, not just attempt to treat it. We are committed to offering top-notch quality care, emphasizing that our patient’s safety is always our number one priority.

Miami Stem Cell® continues to be the leading institute in the clinical application of Stem Cell Treatments in America and we effectively treat a wide variety of conditions with minimally invasive procedures that include:

  • Arthritis (pain in the knee, shoulders, hips, spine, cervix and other joints).
  • Sports injuries (Tennis Player’s Elbow, Golfer’s Shoulder, etc.).
  • Degeneration of lumbar discs / Sciatica and pain in the lower back.
  • Fibromyalgia.
  • Tendinitis / Carpal Tunnel.

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  • Sexual dysfunction in men and women.
  • Congestive Heart Disease.
  • Coronary artery disease.
  • Peripheral Vascular Condition.
  • Asthma / COPD / Respiratory problems.

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  • Urinary incontinence.
  • Hair restoration.
  • Facial, neck and hand rejuvenation.
  • Intravenous Multi-Vitamin infusions.
  • Micro-Nutritional Testing / Micro-Nutrition.

In addition, Miami Stem Cell® conducts a comprehensive pre-procedure evaluation that encompasses a variety of medical tests that provide complete information about your overall health that even includes tumor marker screening. These medical tests help our team of experts identify any possible problems before your Stem Cell Procedure and avoid potential complications after your transplant, a series of extra precautions that many other Stem Cell Clinics do not perform.

For more information or to schedule a free evaluation with our team of experts, please call Miami Stem Cell® at (305) 598-7777 or 1 -855-598-CELL or via email: info@stemcellmia.com

You can visit our website:  www.stemcellmia.com or follow us on Facebook, Instagram, Twitter and watch real patients tell their story in videos on our YouTube channel.

“Let Your Own Body Heal You”

Miami Stem Cell 475 Biltmore Way suite 307 Coral Gables, FL 33134

 

Stem Cell Therapy vs. Joint Replacement for Knee Pain

 

 

While stem cell therapy and knee replacement surgery are both straightforward procedures from an orthopedic standpoint, knee replacement surgery has a higher success rate at the cost of being significantly more invasive. Stem cell therapy is regenerative, meaning that it helps your body rebuild the damage in your knees naturally using your own adult stem cells. Because some people’s bodies react differently to stem cell therapy, the success of the procedure, in terms of pain alleviation, will vary by patient. To learn more about stem cell therapy, contact Miami Stem Cell (305) 598-7777 to schedule a consultation and to see if you are a candidate for this typo on non-invasive treatment.